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目的对非甾体类解热镇痛药尼美舒利颗粒、布洛芬混悬液治疗高热患儿效果和不良反应的比较。方法选择1~13岁的高热患儿120例,随机分为两组,在常规治疗基础上,一组使用尼美舒利颗粒口服3mg/kg,另一组使用布洛芬混悬液口服5mg/kg。测定治疗前、治疗后30min、1h、2h、6h体温,并观察疗效及不良反应。结果尼美舒利组在1h内体温下降幅度比布洛芬组大,而且维持时间长。结论口服尼美舒利颗粒治疗高热患儿较布洛芬混悬液起效快,不良反应小,使用较安全,临床上值得推广使用。
Objective To compare the efficacy and adverse reactions of nimesulide granules and ibuprofen suspension in the treatment of children with hyperthermia. Methods One hundred and thirteen children aged from 1 to 13 with fever were randomly divided into two groups. On the basis of conventional treatment, one group was given nimesulide granule orally 3mg / kg and the other group was given Ibuprofen suspension orally 5mg / kg. Before treatment, after treatment, 30min, 1h, 2h, 6h body temperature, and observe the efficacy and adverse reactions. Results In the nimesulide group, the decrease of body temperature in 1 h was larger than that in the ibuprofen group, and it maintained for a long time. Conclusion Oral nimesulide granules treatment of children with fever than ibuprofen suspension onset faster, less adverse reactions, the use of safer, it is clinically worth promoting.