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目的观察辛伐他汀对老年高胆固醇血症患者降脂治疗的有效性和安全性。方法对38例门诊老年高胆固醇血症患者予晚间服辛伐他汀,剂量10mg,共8周,观察用药前后血浆总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL一C)、肌酸磷酸肌酶(CPK)水平以及肝肾功能变化。结果治疗4周后TC、LDL-C均较前显著下降(P<0.01),8周后HDL-C显著上升(P<0.01),TG浓度明显下降(P<0.05)。总有效率92.11%。治疗前后肝肾功能及CPK无明显变化,仅1例出现轻微的丙氨酸氨基转移酶(ALT)升高,占2.7%,停药后1周复查恢复正常。不良反应轻微,能持续用药。结论辛伐他汀对老年高胆固醇血症患者降脂治疗是有效和安全的,值得推广。
Objective To observe the efficacy and safety of simvastatin on lipid-lowering therapy in elderly patients with hypercholesterolemia. Methods Thirty-eight outpatients with hypercholesterolemia were treated with simvastatin at a dose of 10 mg for 8 weeks. The levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL-C ), Low density lipoprotein (LDL-C), creatine phosphokinase (CPK) and liver and kidney function. Results TC and LDL-C decreased significantly (P <0.01) after 4 weeks treatment, HDL-C increased significantly (P <0.01) and TG concentration decreased significantly after 8 weeks (P <0.05). The total effective rate of 92.11%. Before and after treatment of liver and kidney function and CPK no significant change, only 1 case of mild increase in alanine aminotransferase (ALT), accounting for 2.7%, 1 week after stopping the test returned to normal. Minor adverse reactions, can continue medication. Conclusion Simvastatin is effective and safe for lipid-lowering therapy in elderly patients with hypercholesterolemia, which is worth promoting.