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牛膝多糖（ＡＢＰ）是从中药牛膝根中分离得到的一种有效成分。ＡＢＰ５０－８００ｍｇ·Ｌ－１在体外增强天然杀伤（ＮＫ）细胞活性和促进伴刀豆球蛋白Ａ（ＣｏｎＡ）诱导的肿瘤坏死因子－β（ＴＮＦ－β）产生；但不能提高ＣｏｎＡ诱导的Ｔ淋已细胞增殖反应和白介素２的产生．ＡＢＰ５０及１００ｍｇ·ｋｇ－１ｉｐ明显提高正常小鼠ＮＫ细胞活性和ＴＮＦ─β生成，增强二硝基氟苯诱导的迟发型超敏反应和对抗环磷酰胺对ＮＫ活性的抑制作用。但对ＣｏｎＡ诱导的Ｔ淋巴细胞增殖反应和白介素２的产生无明显影响。表明ＡＢＰ对Ｔ淋巴细胞功能的影响是有选择性的．ＡＢＰ对ＮＫ细胞的杀伤活性的增强作用是明显的．
Achyranthes bidentata polysaccharide (ABP) is an effective ingredient isolated from the root of Achyranthis bidentata. ABP50-800mg·L-1 enhances natural killer (NK) cell activity in vitro and promotes concanavalin A (ConA)-induced tumor necrosis factor-β (TNF-β) production; but it does not increase ConA-induced T-lyase Has cell proliferation and interleukin 2 production. ABP50 and 100 mg·kg-1ip significantly increased NK cell activity and TNF-β production in normal mice, enhanced delayed-type hypersensitivity induced by dinitrofluorobenzene, and inhibited the inhibitory effect of cyclophosphamide on NK activity. However, there was no significant effect on the proliferation of T lymphocytes induced by ConA and the production of interleukin-2. It shows that ABP has a selective effect on the function of T lymphocytes. The enhanced effect of ABP on killing activity of NK cells is obvious.