论文部分内容阅读
目的探讨术前化疗对局部晚期食管癌的影响。方法将2006年1月至2008年1月82例临床分期为Ⅲ期的食管癌患者随机分为两组,实验组40例给予顺铂、5-氟尿嘧啶1～2周期术前化疗,对照组42例直接手术。比较两组手术时间、出血量、并发症发生率、根治性切除率及术后1、3年生存率。结果两组手术时间、出血量、并发症发生率的差异无统计学意义。实验组根治性切除率为87.5%,对照组为40.5%,两组间的差异具有统计学意义。实验组1、3年生存率分别为90.0%、52.5%,对照组分别为59.5%、26.2%,两组间的差异具有统计学意义。结论术前1～2周期顺铂+5-氟尿嘧啶化疗能降低局部晚期食管癌的临床分期,提高根治切除率及1、3年生存率,而不增加手术并发症。
Objective To investigate the effect of preoperative chemotherapy on locally advanced esophageal cancer. Methods From January 2006 to January 2008, 82 patients with stage Ⅲ esophageal cancer were randomly divided into two groups. The experimental group received cisplatin and 5- fluorouracil for 1-2 cycles of preoperative chemotherapy and the control group of 42 Cases of direct surgery. The operation time, blood loss, complication rate, radical resection rate and postoperative 1, 3 year survival rate were compared between the two groups. Results There was no significant difference in the operation time, bleeding volume and complication rate between the two groups. The radical resection rate was 87.5% in the experimental group and 40.5% in the control group, and the difference between the two groups was statistically significant. The 1-year and 3-year survival rates of the experimental group were 90.0% and 52.5%, respectively, while those in the control group were 59.5% and 26.2%, respectively. The difference between the two groups was statistically significant. Conclusions Chemotherapy with cisplatin + 5- fluorouracil 1 ~ 2 cycles preoperatively can reduce the clinical stage of locally advanced esophageal cancer and improve the radical resection rate and 1,3-year survival rate without increasing the complications of surgery.