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Objective:To investigate the relationship between matrix metalloproteinases-9 (MMP-9) and sialyl Lewis X (CD15s) antigen in invasion and metastasis of gastric carcinoma. Methods: Expression of CD105,MMP-9 and CD15s in 47 cases of gastric carcinoma undergone radical surgery were evaluated by SP immunohistochemical staining using the respec-tive monoclonal antibody. The microvessel density (MVD) marked with CD105 was detected. Correlation between MVD and MMP-9,CD15s was also statistically analyzed. Results: The MVD in both MMP-9 and CD15s positive expression group was higher significantly than that in MMP-9 or CD15s positive expression alone group,and it was also significantly higher than that in both MMP-9 and CD15s negative expression group. Conclusion: MMP-9 is a marker of invasion and CD15s is a marker of metastasis in gastric carcinoma. Combining detection of MMP-9 and CD15s has certain clinical significance for diagnosis,treatment and assessing the prognosis for gastric caner.
Objective: To investigate the relationship between matrix metalloproteinases-9 (MMP-9) and sialyl Lewis X (CD15s) antigen in invasion and metastasis of gastric carcinoma. Methods: Expression of CD105, MMP-9 and CD15s in 47 cases of gastric carcinoma undergone radical surgery were evaluated by SP immunohistochemical staining using the respec- tive monoclonal antibody. The microvessel density (MVD) marked with CD105 was detected. Correlation between MVD and MMP- 9 and CD15s positive expression group was higher significantly than that in MMP-9 or CD15s positive expression alone group, and it was also significantly higher than that in both MMP-9 and CD15s negative expression group. invasion and CD15s is a marker of metastasis in gastric carcinoma. Combining detection of MMP-9 and CD15s has certain clinical significance for diagnosis, treatment and assessing the prognosis for gastric caner.