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小檗碱(Berbeerine)是秦巴山区广为分布的中药材三棵针中所含生物碱的主要成分之一,具有清热、利湿、消瘀之功效,临床多用其盐酸盐治疗胃肠炎,临床广为应用的黄莲素就是盐酸小檗碱的俗名,因此利用现代分析手段监测微量小檗碱在主要脏器心、肝、肾的含量就显得特别重要.本文利用小檗碱具有刚性分子结构和弱荧光性的特点,用十二烷基磺酸钠为胶束试剂,在原体系介质中形成荧光探剂,对口服经24 h代谢后,兔体的主要脏器心、肝、肾中分布的微量小檗碱进行了测定.
Berberine (Berbeerine) is one of the main components of the alkaloids contained in the three acupuncture points of the widely distributed traditional Chinese medicine in the Qinling-Bal Mountain area. It has the effects of clearing away heat, dampness and removing blood stasis. Inflammation, clinically widely used berberine is the common name of berberine hydrochloride, the use of modern analytical tools for monitoring trace berberine in the major organs of the heart, liver and kidney content is particularly important.In this paper, berberine has a rigid molecule Structure and weak fluorescence characteristics of sodium dodecyl sulfate as a micellar reagent in the original medium to form a fluorescent agent, after oral administration of 24 h metabolism, the main rabbit heart, liver, kidney Distribution of trace berberine was determined.