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目的观察胃肠安丸对肝郁脾虚型功能性消化不良(FD)模型大鼠胃肠动力及血浆胃动素(MTL)水平的影响。方法将60只实验大鼠随机分为6组(每组10只):对照组,模型组,胃肠安丸高、中、低剂量(50.4、25.2、12.6 mg/kg,中剂量为临床等效剂量)组及多潘立酮片阳性对照组,各组均ig给药,连续7d。给药后测定每组大鼠胃残留率及血浆MTL水平。结果与模型组相比,胃肠安丸高、中剂量组及多潘立酮片组大鼠胃内残留率显著降低(P<0.05);胃肠安丸高剂量组血浆MTL水平与对照组、模型组相比均显著提高(P<0.05);胃肠安丸中剂量组血浆MTL水平显著高于模型组(P<0.05)。结论胃肠安丸可能通过调节MTL水平,改善胃动力,进而发挥对FD的治疗作用。
Objective To observe the effects of Weishen’an Pills on gastrointestinal motility and plasma motilin (MTL) levels in rats with functional dyspepsia (FD) of liver-qi stagnation and spleen deficiency type. Methods Sixty experimental rats were randomly divided into 6 groups (10 in each group): control group, model group, Weisuanan high, medium and low dose (50.4,25.2,12.6 mg / kg, the middle dose is clinically equivalent Dose) and domperidone tablets positive control group, each group were ig administration, continuous 7d. After administration, the gastric residual rate and plasma MTL level in each group were determined. Results Compared with the model group, the gastric residual rate of high-dose, middle-dose and domperidone groups was significantly decreased (P <0.05). Compared with the model group, the high-dose and low- (P <0.05). The plasma MTL level in the middle dose of Weishenan pills group was significantly higher than that in the model group (P <0.05). Conclusion: Weizuo’an pill can improve the gastric motility by regulating the level of MTL and then exert its therapeutic effect on FD.