【摘 要】
：
A commercial albumin-bound paclitaxel nano-formulation has been considered a gold stan-dard against breast cancer.However,its application still restricted unfavorable pharmacokinetics and the immunogenicity of exogenous albumin carrier.Herein,we report an
【机 构】
：
School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 110016,Chin
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A commercial albumin-bound paclitaxel nano-formulation has been considered a gold stan-dard against breast cancer.However,its application still restricted unfavorable pharmacokinetics and the immunogenicity of exogenous albumin carrier.Herein,we report an albumin-bound tumor redox-responsive paclitaxel prodrugs nano-delivery strategy.Using diverse linkages(thioether bond and disul-fide bond),paclitaxel(PTX)was conjugated with an albumin-binding maleimide(MAL)functional group.These pure PTX prodrugs could self-assemble to form uniform and spherical nanoparticles(NPs)in aqueous solution without any excipients.By immediately binding to blood circulating albumin after intravenous administration,NPs are rapidly disintegrated into small prodrug/albumin nanoaggre-gates in vivo,facilitating PTX prodrugs accumulation in the tumor region via albumin receptor-mediated active targeting.The tumor redox dual-responsive drug release property of prodrugs improves the selectivity of cytotoxicity between normal and cancer cells.Moreover,disulfide bond-containing pro-drug/albumin nanoaggregates exhibit long circulation time and superior antitumor efficacy in vivo.This simple and facile strategy integrates the biomimetic characteristic of albumin,tumor redox-responsive on-demand drug release,and provides new opportunities for the development of the high-efficiency anti-tumor nanomedicines.
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