【摘 要】
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Recent infectious disease outbreaks,such as COVID-19 and Ebola,have highlighted the need for rapid and accurate diagnosis to initiate treatment and curb transmission.Successful diagnostic strate-gies critically depend on the efficiency of biological sampl
【机 构】
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School of Pharmacy,Faculty of Medical Sciences,Newcastle University,Newcastle Upon Tyne NE1 7RU,UK;T
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Recent infectious disease outbreaks,such as COVID-19 and Ebola,have highlighted the need for rapid and accurate diagnosis to initiate treatment and curb transmission.Successful diagnostic strate-gies critically depend on the efficiency of biological sampling and timely analysis.However,current diag-nostic techniques are invasive/intrusive and present a severe bottleneck by requiring specialist equipment and trained personnel.Moreover,centralised test facilities are poorly accessible and the requirement to travel may increase disease transmission.Self-administrable,point-of-care(PoC)microneedle diagnostic devices could provide a viable solution to these problems.These miniature needle arrays can detect bio-markers in/from the skin in a minimally invasive manner to provide(near-)real-time diagnosis.Few mi-croneedle devices have been developed specifically for infectious disease diagnosis,though similar technologies are well established in other fields and generally adaptable for infectious disease diagnosis.These include microneedles for biofluid extraction,microneedle sensors and analyte-capturing micronee-dles,or combinations thereof.Analyte sampling/detection from both blood and dermal interstitial fluid is possible.These technologies are in their early stages of development for infectious disease diagnostics,and there is a vast scope for further development.In this review,we discuss the utility and future outlook of these microneedle technologies in infectious disease diagnosis.
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