Alteration of encephalomyocarditis virus pathogenicity due to a mutation at position 100 of VP1

• 作 者: ZHU Shu GE XinNa GONG XiaoWen
• 机 构: KeyLaboratoryofZoonosisofMinistryofAgriculture
• 出 处: 中国科学：生命科学英文版
• 发表日期: 2011年6期
• 关键词: 脑心肌炎病毒 基因突变 致病性 VP1 病毒感染 CDNA克隆 异亮氨酸 氨基酸 encephalomyocarditis virus （EMCV） VP1 m
• 基金项目: supported by the National Natural Science Foundation of China （Grant No. 30530550）, the Program for Innovative Research Team in University of China （Grant No. IRT0866）

Encephalomyocarditis virus (EMCV) infection leads to many diseases including encephalitis,myocarditis and diabetes in its natural host,the mouse.In this study,we generated four cDNA clones with a point mutation at position 100 of VP1.The amino acids isole