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1951年Wangensteen等首先提出结直肠癌根治切除后1年行第二次手术(Second-look operation,SLO)。SLO对早期发现的复发性结直肠癌病人治疗有效,但6.2％5年生存率和50％阴性率使SLO未被广泛接受。术后癌胚抗原(CEA)水平监测和影像手段的改善掀起SLO的新热潮,成为复发者治疗最有效方法。
In 1951 Wangensteen et al. first proposed a second-look operation (SLO) 1 year after radical resection of colorectal cancer. SLO is effective for early detection of recurrent colorectal cancer patients, but the 6.2% 5-year survival rate and 50% negative rate make SLO not widely accepted. The monitoring of post-operative carcinoembryonic antigen (CEA) levels and the improvement of imaging methods have created a new upsurge of SLO and become the most effective treatment for relapsers.