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一、帕金森病在中枢神经变■■■病中,帕金森病的病理及生化改变了解得最为清楚,以此为基础,治疗上也取得了很大成绩,成为变性性疾病研究的典范。帕金森病治疗的根本是左旋多巴补充治疗。但是近年来在左旋多巴长期使用中出现减效及断续(on and off)现象等,成为今后研究的重点。 1.左旋多巴缓释剂 1989年11月出版的《神经病学》杂志专门介绍了左旋多巴缓释剂。记录了1989年4月伦敦讨论会的精神,着重讨论了5个方面的问题。①常规左旋多巴治疗存在的问题,②缓释剂的药代动力学,③症状变化的治疗,④缓释剂治
First, the Parkinson’s disease in the central nervous system ■ ■ ■ disease, Parkinson’s disease pathology and biochemical changes understand most clearly, as a basis, the treatment has also made great achievements, as a model of degenerative diseases. The fundamental treatment of Parkinson’s disease is levodopa replacement therapy. However, in recent years, the long-term use of levodopa appear to reduce and intermittent (on and off) phenomenon, become the focus of future research. 1. Levodopa Extended Release The November 1989 issue of Neurology specifically describes the release of levodopa. The spirit of the London Symposium of April 1989 was recorded, focusing on five aspects. ① routine levodopa treatment of existing problems, ② sustained-release pharmacokinetics, ③ the treatment of symptoms, ④ slow-release treatment