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目的：探讨西酞普兰与万拉法新治疗老年抑郁症的疗效和安全性。方法将108例老年抑郁症患者随机分为两组，各54例，分别给予西酞普兰和万拉法新治疗，疗程6周，采用汉密尔顿抑郁量表（HAMD）、临床疗效总评量表的病情严重程度（CGI-SI）和副反应量表（TESS）评定疗效和不良反应。结果西酞普兰与万拉法新治疗老年性抑郁症疗效相近，但前者不良反应较后者少而轻微。结论西酞普兰可作为治疗老年抑郁症的首选用药。“,”Objective To explore the efficacy and side effects of citalopram in the treatment of depression. Methods 108 patients with aged depression were double-blindly assigned to citalopram group and venlafaxine group for 6 weeks. HAMD,CGI and TESS were used to assess the clinical efficacy and side effects. Results Citalopram possessed efficacy similar to venlafaxine. However citalopram had fewer side effects. Conclusion Citalopram may be first drug for treating aged depression.