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业已发现,鼠类、猿猴和人类疟原虫的血液期裂殖体所合成的高分子量蛋白,能使宿主产生保护性免疫应答。自约氏疟原虫提取的230,000MW蛋白质,可使免疫小鼠产生抵抗攻击感染的能力。抗夏氏疟原虫250,000MW蛋白质的单克隆抗体(MAbs)输给小鼠后,能抑制感染小鼠的原虫血症。恶性疟原虫合成的195,000MW蛋白质,能与免疫血清呈强反应。本文在于鉴定上述3种高分子量蛋白质的血清学关系。
It has been found that high molecular weight proteins synthesized by the blood schizonts of murine, simian and human Plasmodium can produce a protective immune response to the host. The 230,000 MW of protein extracted from Plasmodium yoelii causes the immunized mice to develop the ability to fight infection. Monoclonal antibodies (MAbs) against 250,000 megawatts of Plasmodium malariae are administered to mice to inhibit parasitemia in infected mice. The 195,000 megawatt protein synthesized by Plasmodium falciparum strongly reacts with immune sera. The purpose of this article is to identify serological relationships among the three high molecular weight proteins described above.