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本文报告1例服用乙胺碘呋酮引起的帕金森综合征。病例患者男性,73岁。因缺血性心脏病伴阵发性房性心律失常和室性心动过速予以乙胺碘呋酮治疗,头2日为每6小时1次,每次400mg,以后减至每8小时1次,每次400mg。用药第4天左下肢出现间歇性类似帕金森病的6-Hz 粗大静止性震颤,次日停药。震颤多局限于左足有时也涉及整个左下肢,仅见于卧位静止时,起动后震颤消失。没有头、下颌、语音、臂或右腿震颤,也没出现音调改变、运动徐缓,步态紊乱及姿势不稳等症象。血象、常规血液化学、甲状腺扫描、脑电图、脑核磁共振显象
This article reports 1 patient taking amiodarone-induced Parkinson’s syndrome. Case patient male, 73 years old. Due to ischemic heart disease with paroxysmal atrial arrhythmia and ventricular tachycardia were treated with amiodarone, the first 2 days every 6 hours once every 400mg, later reduced to once every 8 hours, Each 400mg. On the fourth day of treatment, an intermittent 6-Hz, restful tremor of Parkinson’s disease appeared on the lower extremity and was discontinued the next day. Tremor and more limited to the left foot sometimes involves the entire left lower limb, only seen when the supine position is still, tremor disappeared after starting. No head, jaw, voice, arm or right leg tremor, nor change in tone, slow movement, gait disorders and postural instability and other symptoms. Blood, conventional blood chemistry, thyroid scan, EEG, brain MRI