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目的检测乳腺癌中血管内皮生长因子-c(VEGF-c)的表达,探讨其临床意义。方法采用免疫组织化学方法检测78例乳腺浸润性导管癌组织标本中VEGF-c的表达,以活检证实的30例乳腺良性病变作为对照组,结合临床资料进行统计学分析。结果乳腺癌伴淋巴结转移的患者VEGF-c表达率为70.0%,ER阴性者VEGF-c表达率为73.2%,其5年生存率低于VEGF-c阴性患者;VEGF-c的表达与肿瘤大小及患者年龄无关。结论 VEGF-c在乳腺癌中的高表达可能是肿瘤发生过程中的一个重要因素,其表达的蛋白产物可作为临床上乳腺癌诊断、治疗、预后判断的一个重要指标。
Objective To detect the expression of vascular endothelial growth factor-c (VEGF-c) in breast cancer and to investigate its clinical significance. Methods Immunohistochemistry was used to detect the expression of VEGF-c in 78 cases of invasive ductal carcinoma of the breast. Thirty cases of benign breast lesions confirmed by biopsy were used as control group, and the clinical data were used for statistical analysis. Results The positive rate of VEGF-c was 70.0% in patients with breast cancer with lymph node metastasis and 73.2% in ER-negative patients, and the 5-year survival rate was lower than that in patients with negative VEGF-c. The expression of VEGF-c was correlated with tumor size And the patient’s age has nothing to do. Conclusion The high expression of VEGF-c in breast cancer may be an important factor in the process of tumorigenesis. The expressed protein can be used as an important index in the diagnosis, treatment and prognosis of clinical breast cancer.