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目的观察利福喷丁对HBsAg阳性肺结核患者肝功能影响。方法利用福喷丁和利福平治疗HBsAg阳性肺结核患者,观察治疗前后肝功能损害情况。结果利福平较利福喷丁更易发生肝功能损害;HBsAg阳性患者病毒复制量与利福喷丁对肝功能的损害无关。结论利福喷丁肝功能损害程度低,HBsAg阳性患者抗结核治疗时比阴性者更易发生肝损害,HBsAg阳性肺结核患者病毒复制量与肝损害无明显相关性。
Objective To observe the effects of rifapentin on liver function in patients with HBsAg positive pulmonary tuberculosis. Methods Fufang Ding and rifampicin were used to treat patients with HBsAg positive pulmonary tuberculosis, liver function damage was observed before and after treatment. Results Rifampicin was more prone to liver damage than rifapentine. The amount of viral replication in HBsAg-positive patients was not related to the impairment of liver function by rifapentine. Conclusions Rifampicin has a low degree of hepatic impairment. HBsAg-positive patients are more susceptible to liver damage than negative ones in HBsAg-positive patients. There is no significant correlation between viral replication and liver damage in patients with HBsAg-positive pulmonary tuberculosis.