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目的探讨鼠神经生长因子注射液治疗高原新生儿缺氧缺血性脑病(hypoxic-ischemic encephalpethy,HIE)的临床疗效。方法将2008-12-2011-01期间来自海西州第二人民医院住院的HIE患儿40例随机分为两组,对照组予以采用HIE三支持、三对症的综合治疗方案,并于脑水肿急性期过后常规营养脑神经药物治疗,治疗组在对照组治疗基础上加用鼠神经生长因子注射液。结果治疗组总有效率95%,对照组总有效率80%,两组间疗效比较差异有统计学意义(P<0.05)。结论鼠神经生长因子注射液治疗高原新生儿缺氧缺血性脑病有显著疗效。
Objective To investigate the clinical efficacy of rat nerve growth factor injection in the treatment of neonatal hypoxic-ischemic encephalpethy (HIE). Methods Forty HIE infants admitted from the Second People’s Hospital of Haixi Prefecture between December 2008 and December 2011 were randomly divided into two groups. The control group was given three supportive and three symptomatic comprehensive treatment regimens, After the acute phase of conventional nutritional brain nerve drug treatment, the treatment group in the control group based on the addition of mouse nerve growth factor injection. Results The total effective rate was 95% in the treatment group and 80% in the control group, with significant difference between the two groups (P <0.05). Conclusion NGF injection has a significant effect in treating neonatal hypoxic-ischemic encephalopathy in the plateau.