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目的用莫西沙星、特非那定和卡托普利对犬植入式生物遥测技术进行性能评价研究。方法 4只埋植有遥测植入子的清醒Beagle犬,通过拉丁方设计,在4个不同的给药日分别ig给予空白胶囊、莫西沙星、特非那定和卡托普利30 mg/kg,用DSI遥测系统连续采集给药前2 h至给药后24 h的生理信号,对心电、血压、体温等数据进行分析,比较给药前与给药后各时间点各指标的差异。结果空白胶囊对犬的各项生理指标无明显影响;给予莫西沙星和特非那定后,犬QT间期及校正的QT间期(QTc)与给药前比较,出现不同程度的延长;给予卡托普利对犬的心电参数无影响但显著降低血压。结论植入式生物遥测技术可灵敏的检测到药物对清醒犬心血管系统的影响,可用于安全药理研究和清醒犬心血管模型研究。
Objective To evaluate the performance of implantable biological telemetry using moxifloxacin, terfenadine and captopril. METHODS: Four conscious Beagle dogs embedded with telemetry implants were injected with blank capsules, moxifloxacin, terfenadine and captopril 30 mg / kg on four different dosing days by Latin square design. kg, DSI telemetry system was used to continuously collect physiological signals from 2 h before treatment to 24 h after administration, and the data of ECG, blood pressure and body temperature were analyzed. The differences of each index before and after administration were compared . Results Blank capsules had no significant effect on the physiological indexes of dogs. QT interval and corrected QT interval (QTc) in dogs were prolonged to some extent after administration of moxifloxacin and terfenadine. Given Captopril no effect on the dog’s ECG parameters but significantly lower blood pressure. Conclusion Implanted bio-telemetry can sensitively detect the effects of drugs on the cardiovascular system of awake dogs and can be used in safety pharmacological studies and awake canine cardiovascular models.