Pancreatic metastasis from mycosis fungoides mimicking primary pancreatic tumor

• 作 者: Paola Ceriolo Valentina Fausti Elisa Cinotti Silvia Bonadio Lizzia Raffaghello Giovanna Bianchi Giulio Fraternali Orcioni Roberto Fiocca Franco Rongioletti Vito Pistoia Giacomo Borgonovo
• 机 构: Course in Paediatric Science, Fetal-Perinatal and Paediatric Pathology, University of Genoa,Patholog
• 出 处: World Journal of Gastroenterology
• 发表日期: 2016年12期
• 关键词: metastasis metastatic pancreas dissemination localization glucagon neoplasm prog

Mycosis fungoides(MF) is a cutaneous T-cell lymphoma that can undergo local progression with possible systemic dissemination. We report a case of a patient affected by MF with a pancreatic mass that was a diagnostic challenge between primitive tumor and pancreatic metastasis from MF. Clinical setting findings and imaging studies raised the suspicion of a pancreatic primary neoplasm. A diagnostic clue was provided by the combined histomorphologic/immunohistochemical study of pancreatic and cutaneous biopsies, which revealed a pancreatic localization of MF. Considering the rarity of metastatic localization of MF to the pancreas, we next investigated whether chemokinechemokine receptor interactions could be involved in the phenomenon to provide new insight into the possible mechanisms underlying metastatic localization of MF to the pancreas. Histological analyses of archival pancreatic tissue demonstrated that glucagon-secreting cells of the pancreatic islets expressed the CCL27 chemokine, which may have attracted in our case metastatic MF cells expressing the complementary receptor CCR10.

My report on a case of a patient affected by MF with a pancreatic mass that was a diagnostic challenge between primitive tumor and pancreatic metastasis from MF. Clinical setting findings and imaging studies raised the suspicion of a pancreatic primary neoplasm. A diagnostic clue was provided by the combined histomorphologic / immunohistochemical study of pancreatic and cutaneous biopsies, which revealed a pancreatic localization of MF. Considering the rarity of metastatic localization of MF to the pancreas, we next ploidy of chemokinechemokine receptor interactions could be involved in the phenomenon to provide new insight into the possible mechanisms underlying metastatic localization of MF to the pancreas. Histological analyzes of archival pancreatic tissue of the glucagon-secreting cells of the pancreatic islets expressed the CCL27 chemokine , which may have attract in our case metastatic MF cells expressing the complementary receptor CCR10.