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羊水栓塞是分娩时骤然死亡的主要原因之一。弥散性血管内凝血(DIC)是羊水栓塞的主要组成部分,亦是应用肝素治疗的基础;但是,对使用肝素的时间尚无统一看法。本文作者为此对200只体重150～200g的妊娠晚期初孕家鼠进行了研究。采用10名健康产妇的羊水混合物。在混合物注入鼠体前,先用0.14mol的氯化钠溶液将其稀释,使羊水能将等量再钙化血浆的凝结时间缩短一半;将羊水注入经乙醚麻醉后的鼠颈静脉内,此后过半分钟、15分钟、1、6、13、及18小时取血样以测定其再钙化时间、凝血酶原时间、部分凝血酶原时间、凝血酶时间、抗凝血酶Ⅲ、纤维蛋白原、纤维蛋白溶解、血小板含量、鱼精蛋白副凝试验、乙醇胶凝试验,出血量及出血持续时间。使用肝素的剂量取决于栓塞时渗入机体的羊水
Amniotic fluid embolism is one of the major causes of sudden death during labor. Disseminated intravascular coagulation (DIC) is a major component of amniotic fluid embolism and is also the basis for the use of heparin therapy; however, no time is available for the use of heparin. The author of this article on the 200 weighing 150 ~ 200g late pregnancy late pregnant rats were studied. Amniotic fluid mixture of 10 healthy mothers. Before the mixture was injected into the mouse, it was diluted with 0.14 mol of sodium chloride solution so that the amniotic fluid could shorten the setting time of the same amount of recalcified plasma by half. The amniotic fluid was injected into the jugular vein of a rat anesthetized with ether, Blood samples were taken at 15 minutes, 1 minute, 1 minute, 1 minute, 1 minute, 15 minutes, 1, 6, 13 and 18 hours to determine the time of re-calcification, prothrombin time, partial prothrombin time, thrombin time, antithrombin III, fibrinogen, fibrin Dissolution, platelet content, protamine coagulant test, ethanol gel test, bleeding volume and duration of bleeding. The dose of heparin used depends on the amount of amniotic fluid that penetrates into the body during embolization