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许多证据表明,分娩时母体血浆和羊水中的前列腺素F_(2α)α(PGFM)水平显著升高。胎儿镜检查的一种明显危险是引起自发流产,因此作者决定研究胎儿镜对母体血浆内PGFM水平的影响。在62例妊娠14～23周的孕妇中进行胎儿镜检查,然后采集外周血,用放射免疫法测定血浆内13,14-二氢-15-氧-前列腺素F_2α浓度。胎儿镜检查前的PGFM平均浓度为410.1±115.8pmol/l(平均数±SD),检查后的10分钟和20分钟时的值分别为440.9±125.6和394.4±103.3pmol/l,其差异无统计学意义。作者研究的结果表明,妊娠14～23周孕妇的血浆PGFM无明显变化,这与以前研究的孕龄增加其前列腺素水平不升高的结果相一致。然而在分娩时母体血浆和羊水中的前列腺素水平逐渐升高。众所周知,子宫组织受创伤时则刺激前列腺素合成。羊膜穿刺术不仅引起前列腺素快速、持续的
There is ample evidence that prostaglandin F_ (2α) α (PGFM) levels are significantly elevated in maternal plasma and amniotic fluid during labor. A significant risk of fetal examination is spontaneous abortion, so the authors decided to study the effect of fetoscope on PGFM levels in maternal plasma. Fetal endoscopy was performed in 62 pregnant women 14 to 23 weeks of gestation. Peripheral blood was collected and the plasma concentration of 13,14-dihydro-15-oxo-prostaglandin F_2α was measured by radioimmunoassay. The mean PGFM concentration before fetoscopy was 410.1 ± 115.8 pmol / l (mean ± SD), with values of 440.9 ± 125.6 and 394.4 ± 103.3 pmol / l at 10 and 20 minutes after the test, respectively, with no statistical difference Significance of learning. The authors study results show that pregnant women 14 to 23 weeks pregnant PGFM no significant change in plasma, which is consistent with the previous study of gestational age does not increase its prostaglandin levels consistent results. However, the level of prostaglandins in maternal plasma and amniotic fluid increases gradually during childbirth. It is well known that uterine tissue stimulates prostaglandin synthesis when traumatized. Amniocentesis not only causes prostaglandins to be rapid and persistent