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目的探讨原发性高血压患者血清IGF-Ⅰ、VEGF、CRP、UA及Hcy的变化与血压分级和心室肥厚的相关性。方法选取2009年1月～2011年5月于本院进行治疗的60例原发性高血压患者为研究对象,将其设为观察组,同时选取同期的60名健康人为对照组,ELISA法检测两组人员的血清IGF-Ⅰ、VEGF、CRP、UA及Hcy水平,并将高血压患者分为三个等级,心室肥厚与否分为两类,运用统计学方法比较分析。结果观察组的血清IGF-I、VEGF、CRP、UA及Hcy水平均高于对照组(P<0.05),且血压分级越高者其水平也越高,且伴有心室肥厚者高于不伴有心室肥厚者,差异具有统计学意义(P<0.05)。结论原发性高血压患者血清IGF-I、VEGF、CRP、UA及Hcy水平与血压分级及是否伴有心室肥厚均有较大的相关性,具有重要的临床指导意。
Objective To investigate the relationship between the changes of serum IGF-Ⅰ, VEGF, CRP, UA and Hcy in patients with essential hypertension and the classification of blood pressure and ventricular hypertrophy. Methods Sixty patients with essential hypertension who were treated in our hospital from January 2009 to May 2011 were selected as the observation group and 60 healthy people in the same period as the control group. Serum levels of IGF-Ⅰ, VEGF, CRP, UA and Hcy in the two groups were divided into three grades. Hypertensive patients were divided into two groups according to statistical methods. Results The levels of serum IGF-I, VEGF, CRP, UA and Hcy in the observation group were higher than those in the control group (P <0.05), and the higher the level of blood pressure was, the higher the level of serum IGF- There are ventricular hypertrophy, the difference was statistically significant (P <0.05). Conclusion The serum levels of IGF-I, VEGF, CRP, UA and Hcy in patients with essential hypertension are closely related to the grading of blood pressure and the presence or absence of ventricular hypertrophy. It has important clinical significance.