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目的探讨应用磷酸肌酸钠治疗急性心肌梗死心力衰竭的临床疗效。方法将57例发病1～7d内的急性心肌梗死伴心力衰竭患者随机分为对照组(28例)和治疗组(29例)。两组均给予抗凝、抗血小板、调脂、扩血管、利尿、强心等基础治疗。治疗组加用注射用磷酸肌酸钠1g溶于0.9%氯化钠溶液100ml,2次/d,静脉滴注,观察10d。结果治疗组总有效率明显高于对照组(93.1%vs 82.1%),(t=8.33,P<0.05);两组治疗后左室射血分数及血浆BNP下降水平均明显改善((t=7.84,P<0.01),且治疗组优于对照组(P<0.05)。结论注射用磷酸肌酸钠能改善急性心肌梗死心力衰竭患者的临床症状及左心室射血分数、降低血浆脑钠肽(BNP),提高临床疗效。
Objective To investigate the clinical efficacy of sodium creatine phosphate in the treatment of heart failure due to acute myocardial infarction. Methods Fifty - seven acute myocardial infarction patients with heart failure within 1 ~ 7 days after onset were randomly divided into control group (n = 28) and treatment group (n = 29). Both groups were given anticoagulant, anti-platelet, lipid-lowering, vasodilator, diuretic, cardiac and other basic treatment. The treatment group plus injection of sodium phosphorylate 1g dissolved in 0.9% sodium chloride solution 100ml, 2 times / d, intravenous infusion, observed 10d. Results The total effective rate of the treatment group was significantly higher than that of the control group (93.1% vs 82.1%, t = 8.33, P <0.05). The left ventricular ejection fraction and the plasma BNP level decreased significantly after treatment (t = 7.84, P <0.01), and the treatment group was better than the control group (P <0.05) .Conclusion Sodium Phosphate injection can improve clinical symptoms and left ventricular ejection fraction in patients with acute myocardial infarction and reduce plasma brain natriuretic peptide (BNP), improve clinical efficacy.