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研究证明相当比例的急性淋巴细胞白血病(ALL)复发时常伴有分化抗原的丢失,认为复发的ALL可能起源于一个分化较低的白血病亚克隆。但细胞遗传学和基因重排的研究结果证明,复发病例仍起源于同一克隆。免疫表型分析发现初治的B和T-ALL常伴有髓系相关抗原CD13、CD33及干细胞抗原CD34的表达,但复发时的详细情况尚无报告。 作者分析了128例(69例儿童、59例成人)ALL第一次复发时的免疫表型并与初诊时的特点比较。结果:共有59例(46％)发生免疫表型变化,其中T-
Studies have shown that a significant proportion of acute lymphoblastic leukemia (ALL) recurrence often accompanied by the loss of differentiation of the antigen that relapsed ALL may originate in a less differentiated subclone of leukemia. But the results of cytogenetics and gene rearrangement study proved that the recurrence of cases still originated in the same clone. Immunophenotypic analysis found that naive B and T-ALL often accompanied by myeloid associated antigen CD13, CD33 and stem cell antigen CD34 expression, but the details of the recurrence has not been reported. The authors analyzed the immunophenotype of 128 patients (69 children, 59 adults) with ALL at the first relapse and compared them with those at first visit. Results: A total of 59 cases (46%) had immunophenotypic changes, of which T-