论文部分内容阅读
目的探讨无创正压通气(NIPPV)对COPD合并肺性脑病患者呼吸功能及认知功能的影响。方法选择2014年5月至2016年5月收治的80例COPD合并肺性脑病患者,按照随机数字表法分为观察组和对照组,每组各40例。观察组给予NIPPV治疗,对照组给予常规治疗,治疗时间为2周。治疗后,观察两组患者动脉血氧分压(PaO_2)、动脉二氧化碳分压(PaCO_2)、血氧饱和度(SaO_2)、第一秒用力呼气量(FEV1)、用力肺活量(FVC)、呼气流量峰值(PEF)、第一秒用力呼气量(FEV1)/用力肺活量(FVC)比值以及简易精神状态量表(MMSE)评分情况。结果观察组患者PaO_2和SaO_2水平上升幅度和PaCO_2下降幅度均明显大于对照组,差异有统计学意义(P<0.05);观察组患者FEV1、FVC、PEF、FEV1/FVC水平上升幅度均显著高于对照组(P<0.05);MMSE评分观察组下降幅度显著大于对照组,差异有统计学意义(P<0.05)。结论 NIPPV可改善COPD合并肺性脑病患者肺泡通气情况,增强血氧饱和度,提高患者呼吸功能和认知能力,值得临床推广。
Objective To investigate the effect of non-invasive positive pressure ventilation (NIPPV) on respiratory function and cognitive function in COPD patients with pulmonary encephalopathy. Methods Eighty patients with COPD with pulmonary encephalopathy admitted from May 2014 to May 2016 were divided into observation group and control group according to the random number table method, 40 cases in each group. The observation group was given NIPPV treatment while the control group was given conventional treatment for 2 weeks. After treatment, the PaO_2, PaCO_2, SaO_2, FEV1, FVC, PEF, FEV 1, FVC and MMSE scores were measured. Results The increase rate of PaO_2 and SaO_2 and the decrease of PaCO_2 in observation group were significantly higher than those in control group (P <0.05). The increase of FEV1, FVC, PEF and FEV1 / FVC in observation group were significantly higher than those in control group (P <0.05). The decrease of MMSE score in the observation group was significantly greater than that in the control group (P <0.05). Conclusion NIPPV can improve the alveolar ventilation in COPD patients with pulmonary encephalopathy, enhance the oxygen saturation and improve the respiratory function and cognitive ability of patients with COPD, which is worthy of clinical promotion.