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目的通过测定妊娠期高血压疾病患者静脉血及新生儿血脂水平,评估妊娠期高血压疾病患者胎儿血脂异常状态。方法选择2014年1月至2014年12月妊娠期高血压疾病患者30例作为观察组,孕期血压水平正常孕妇60例作为对照组。搜集孕妇年龄、产次、孕周、产前体重、孕前体重及合并妊娠期糖尿病情况。在孕妇分娩当天,检测孕妇空腹甘油三酯、胆固醇、高密度脂蛋白和低密度脂蛋白水平;并检测新生儿脐血甘油三酯、胆固醇、高密度脂蛋白和低密度脂蛋白水平。比较两组脐血中血脂水平的差异及其与孕妇血脂水平的相关性。结果妊娠期高血压疾病孕妇甘油三酯和胆固醇水平均高于正常妊娠组[甘油三酯:(4.029±2.25)mmol/L vs(2.35±0.87)mmol/L,P=0.001;胆固醇:(6.06±1.89)mmol/L vs(5.19±1.01)mmol/L,P=0.036],差异有统计学意义。妊娠期高血压病新生儿脐血甘油三酯水平高于正常妊娠组[(0.432±0.23)mmol/L vs(0.259±0.17)mmol/L,P=0.005],高密度脂蛋白水平低于正常妊娠组[(0.650±0.15)mmol/L vs(0.768±0.23)mmol/L,P=0.035],差异有统计学意义。结论妊娠期高血压疾病孕妇和新生儿均存在血脂代谢异常,在孕妇表现为高甘油三酯和高胆固醇,而在新生儿表现为高甘油三酯和低的高密度脂蛋白水平。
Objective To assess the level of serum lipids in patients with hypertensive disorder complicating pregnancy and to assess the status of fetal dyslipidemia in patients with gestational hypertension. Methods Thirty patients with hypertensive disorders during pregnancy from January 2014 to December 2014 were selected as observation group and 60 pregnant women with normal blood pressure during pregnancy as control group. Collect maternal age, parity, gestational age, prenatal weight, pre-pregnancy weight and gestational diabetes mellitus. Fasting triglyceride, cholesterol, high-density lipoprotein and low-density lipoprotein were detected in pregnant women on the day of delivery, and neonatal cord blood triglyceride, cholesterol, high density lipoprotein and low density lipoprotein levels were measured. The differences of blood lipid levels in cord blood and their correlations with blood lipid levels in pregnant women were compared. Results The levels of triglyceride and cholesterol in pregnant women with gestational hypertension were significantly higher than those in normal pregnancy (triglyceride: 4.029 ± 2.25 mmol / L vs 2.35 ± 0.87 mmol / L, P = 0.001; ± 1.89 mmol / L vs 5.19 ± 1.01 mmol / L, P = 0.036]. The difference was statistically significant. The levels of umbilical triglyceride in neonates with gestational hypertension were significantly higher than those in normal pregnancy [(0.432 ± 0.23) mmol / L vs (0.259 ± 0.17) mmol / L, P = 0.005] Pregnancy group [(0.650 ± 0.15) mmol / L vs (0.768 ± 0.23) mmol / L, P = 0.035], the difference was statistically significant. Conclusions Both pregnant women and newborns with hypertensive disorder complicating pregnancy have dyslipidemia, high triglycerides and high cholesterol in pregnant women, and high triglycerides and low high density lipoprotein in newborns.