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随着机械通气在新生儿临床的广泛应用,呼吸机相关性肺炎(Ventilator Associated Pneumonia,VAP)成为新生儿重症监护病房(Neonatal intensive care unit,NICU)内仅次于新生儿败血症的获得性感染。VAP是指原无肺部感染的患者,机械通气48 h后发生肺部感染,或原有肺部感染,机械通气治疗48 h以上发生新的肺部感染[2]。VAP的发病率达10%～65%[2],其主要高危因素有机械通气时间、早产、原发疾患、某些药物的使用等,相应的预防措施也不断被提出并实施应用。近年来国内外医学工
Ventilator Associated Pneumonia (VAP) becomes the second most acquired secondary infection of neonatal sepsis in Neonatal Intensive Care Unit (NICU) with the widespread use of mechanical ventilation in neonatal clinics. VAP refers to the original non-pulmonary infection in patients with mechanical ventilation after 48 h of lung infection, or the original lung infection, mechanical ventilation for more than 48 h after the new pulmonary infection [2]. VAP incidence rate of 10% to 65% [2], the main risk factors are mechanical ventilation time, premature birth, primary disease, the use of certain drugs, the corresponding preventive measures have been continuously put forward and implemented. In recent years, medical workers at home and abroad