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目的探索进展期胃癌患者根治术后行早期肠内营养(enteral nutrition,EN)的疗效和安全性。方法选择2008年12月至2013年4月期间内蒙古医科大学附属医院收治的70例行根治性手术的进展期胃癌患者,将患者随机分为EN组35例和肠外营养(parenteral nutrition,PN)组35例,记录并比较2组患者的营养指标和康复指标。结果术前2组患者的白细胞计数、血浆清蛋白(ALB)、前清蛋白(PA)及转铁蛋白(TRF)水平比较差异均无统计学意义(P>0.05);术后3 d和7 d,除白细胞计数为EN组低于PN组外(P<0.05),ALB、PA及TRF水平均是EN组高于PN组(P<0.05)。EN组患者的术后住院时间和住院费用均短于或低于PN组(P<0.05),而2组患者的术后排气时间和并发症发生率比较差异均无统计学意义(P>0.05)。结论 EN是一种安全、有效及经济的营养补给方法,是进展期胃癌患者术后早期首选的营养支持方法,值得在临床推广。
Objective To explore the efficacy and safety of early enteral nutrition (EN) after radical operation in patients with advanced gastric cancer. Methods Seventy patients with advanced gastric cancer undergoing radical surgery admitted to the Affiliated Hospital of Inner Mongolia Medical University from December 2008 to April 2013 were randomly divided into 35 patients with EN and 35 patients with parenteral nutrition (PN) Group 35 cases, record and compare the two groups of patients nutritional indicators and rehabilitation indicators. Results There were no significant differences in leucocyte count, serum albumin (ALB), prealbumin (PA) and transferrin (TRF) between the two groups before operation (P> 0.05) d. The levels of ALB, PA and TRF in EN group were higher than that in PN group (P <0.05) except leukocyte count was lower in EN group than in PN group (P <0.05). The postoperative hospital stay and hospitalization costs of EN group were both shorter and lower than those of PN group (P <0.05), while there was no significant difference in postoperative exhaust time and complication rate between the two groups (P> 0.05). Conclusion EN is a safe, effective and economical method of nutritional supplementation. It is the first choice of nutritional support for patients with advanced gastric cancer after surgery, which is worthy of clinical promotion.