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目的:探讨阿托品静脉泵入与间断静脉注射治疗有机磷中毒的临床效果。方法:选取怀集县人民医院急诊2014年5月至2016年5月收治的有机磷中毒患者80例,以随机数字表法分组,观察组40例,对照组40例,所有患者均接受常规治疗,A组采取持续静脉泵入阿托品治疗,B组实施间断静脉注射阿托品治疗,对两组患者治疗效果进行观察。结果:A组治疗后阿托品化时间、症状改善时间均较B组短,差异具有统计学意义(P<0.05);A组治疗后治愈率97.50%,后遗症率2.50%,无反跳或药物过量,B组治愈率95.00%,反跳率7.50%,过量率12.50%,后遗症率12.50%,差异具有统计学意义(P<0.05)。结论:阿托品持续静脉泵入治疗有机磷中度可提高疗效,也能缩短见效时间,具有较高安全性。
Objective: To investigate the clinical effect of intravenous injection of atropine and intermittent intravenous injection on organophosphate poisoning. Methods: Eighty patients with organophosphate poisoning who were treated in Huaiji County People’s Hospital from May 2014 to May 2016 were randomly divided into two groups according to random number table: 40 cases in the observation group and 40 cases in the control group. All patients received routine treatment , A group to take continuous intravenous infusion of atropine treatment, B group intermittent intravenous injection of atropine treatment, the treatment effect of two groups were observed. Results: The time of atropisation and the improvement of symptoms in group A were shorter than that in group B (P <0.05). The cure rate of group A was 97.50% and the rate of sequela was 2.50% In group B, the cure rate was 95.00%, the rebound rate was 7.50%, the overdose rate was 12.50% and the sequelae rate was 12.50%. The difference was statistically significant (P <0.05). Conclusion: Atropine continuous intravenous infusion of organic phosphorus can improve the therapeutic effect, but also shorten the effective time, with high safety.