Autonomic and cardiovascular effects of pentobarbital anesthesia during trigeminal stimulation in ca

• 作 者: Hiroshi Hanamoto Hitoshi Niwa Mitsutaka Sugimura Yoshinari Morimoto
• 机 构: Department of Dental Anesthesiology, Osaka University Graduate School of Dentistry, Osaka, Japan
• 出 处: 国际口腔科学杂志（英文版）
• 发表日期: 2012年1期
• 关键词: autonomic nervous system blood pressure and heart rate variability hemodynamics

Stimulation of the trigeminal nerve can elicit various cardiovascular and autonomic responses; however,the effects of anesthesia with pentobarbital sodium on these responses are unclear.Pentobarbital sodium was infused intravenously at a nominal rate and the lingual nerve was electrically stimulated at each infusion rate.increases in systolic blood pressure (SBP) and heart rate (HR) were evoked by lingual nerve stimulation at an infusion rate between 5 and 7 mg.kg-1.h-1.This response was associated with an increase in the low-frequency band of SBP variability (SBP-LF).As the infusion rate increased to 10 mg.kg- 1.h-1 or more,decreases in SBP and HR were observed.This response was associated with the reduction of SBP-LF.In conclusion,lingual nerve stimulation has both sympathomimetic and sympathoinhibitory effects,depending on the depth of pentobarbital anesthesia.The reaction patt seems to be closely related to the autonomic balance produced by pentobarbitai anesthesia.