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目的:假设那些对首次静脉注射丙种球蛋白(IVGG) 无效的川崎病(KD)患儿,如果早期给予额外剂量的IVGG, 有可能防止冠状动脉受损(CAL)。本试验目的在于评价这个假设是否成立。方法:对44例KD患者(17例有CAL和27例没有CAL),因首次IVGG治疗后有持续或反复发热,给予额外剂量的IVGG治疗的情况进行研究。主要观察指标为心脏超声检查CAL的存在及使用
PURPOSE: To hypothesize that children with Kawasaki disease (KD) who are ineffective for first intravenous gamma globulin (IVGG) may prevent coronary artery injury (CAL) if given an additional dose of IVGG early. The purpose of this experiment is to evaluate whether this assumption holds. METHODS: Forty-four patients with KD (17 with CAL and 27 without CAL) were studied for additional IVGG at constant or repeated fever after the first IVGG. The main observation indicators for the presence of cardiac ultrasonography CAL and use