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对中药复方制剂工艺因素和药物成分间的关系应用典型相关分析进行了探讨。结果提示:煎煮时间与大黄素和淫羊藿甙量呈负相关;加水量与大黄素量呈负相关,而与淫羊藿甙呈正相关;浸泡时间与三种成分呈负相关,但影响较小;大黄素和淫羊藿甙受制剂工艺影响较大,而芍药甙几乎不受影响;制剂工艺对中药复方成分的影响为36%,64%的变异可能是由于中药配伍所引起,即配伍对中药成分和药效影响更大。典型相关分析对于中药复方制剂工艺和配伍与成分间的关系研究具有重要的指导意义
The relationship between the technical factors of traditional Chinese medicine compound preparation and the drug composition was discussed by canonical correlation analysis. The results suggest that the decocting time is negatively correlated with the amount of emodin and icariin; the amount of water added is negatively correlated with the amount of emodin and positively correlated with icariin; the soaking time is negatively related to the three components, but the effect is Smaller; emodin and icariin affected by the preparation process, while the paeoniflorin almost no effect; preparation process on the composition of traditional Chinese medicine, the impact of 36%, 64% of the variation may be due to the compatibility of traditional Chinese medicine caused, namely Compatibility of Chinese medicine composition and efficacy greater impact. Canonical correlation analysis has important guiding significance for the study of the relationship between traditional Chinese medicine compound preparation technology and compatibility and composition