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[目的]报道5例胰腺浆液性微囊性腺瘤(SMAP),并探讨其临床病理特征、免疫组化表型、特殊染色、鉴别诊断要点。[方法]对5例发生在胰腺的SMAP患者进行临床资料分析、光学显微镜观察及免疫组化标记和特殊染色,并随访。[结果]SMAP多发生在老年女性,胰腺体尾部是好发部位,临床上表现为腹胀、腹痛、腹部包块等症状或在体检时发现。镜下肿瘤由众多小囊腔组成,囊壁内衬单层立方上皮,胞质内含糖原。免疫组化肿瘤细胞广谱CK、CK7和EMA阳性,CK20、Vim、CK5/6、CEA、Syn、CD10、CD34均阴性,特染PAS阳性。5例病人随访5个月至2年余,未发现复发和转移。[结论]胰腺浆液性微囊性腺瘤是好发于老年女性患者的良性肿瘤,多位于胰腺体尾部,肿瘤切除治疗效果好。
[Objective] The aim of this study was to report 5 cases of pancreatic serous microencapsulated adenoma (SMAP), and to explore its clinical and pathological features, immunohistochemical phenotype, special staining and differential diagnosis. [Method] The clinical data of 5 patients with SMAP in the pancreas were observed, observed by light microscopy, immunohistochemically labeled and stained, and were followed up. [Results] The majority of SMAP occurred in elderly women. The tail of the pancreas was a predilection site. The clinical manifestations were bloating, abdominal pain, abdominal mass and other symptoms or were found during physical examination. Microscope tumor consists of many small cysts, wall lined with single-layer cubic epithelium, cytoplasm containing glycogen. Immunohistochemical tumor cells were positive for CK, CK7 and EMA, negative for CK20, Vim, CK5 / 6, CEA, Syn, CD10 and CD34, respectively. Five patients were followed up for 5 months to more than 2 years, no recurrence and metastasis were found. [Conclusion] Pancreatic serous microencapsulated adenoma is a benign tumor appearing in the elderly female patients, mostly located in the tail of the body of the pancreas. The effect of tumor resection is good.