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目的:评价依那普利与前列地尔联用对糖尿病肾病患者尿蛋白水平及肾功能的影响。方法:选取2015年12月—2016年12月期间收治的糖尿病肾病患者68例,采用随机抽选法将其分成治疗组和对照组,每组34例;对照组患者给予抗凝、降压和胰岛素治疗,治疗组患者在对照组基础上加用依那普利与前列地尔治疗,治疗4周后,比较两组患者的治疗良好率及肾功能,以及治疗前后尿蛋白水平的变化情况。结果:两组患者治疗前24 h尿蛋白测得值经组间比较其差别无统计学意义(P>0.05),治疗后治疗组患者24 h尿蛋白测得值为(1.29±0.13)g,对照组为(1.78±0.32)g(P<0.05),治疗组患者中肾功能总的良好率为91.18%高于对照组为76.47%(P<0.05)。结论:采用依那普利与前列地尔治疗糖尿病肾病患者能够有效改善肾功能和24 h尿蛋白水平。
Objective: To evaluate the effect of enalapril combined with alprostadil on urinary protein and renal function in patients with diabetic nephropathy. Methods: Sixty-eight patients with diabetic nephropathy admitted from December 2015 to December 2016 were selected and randomly divided into treatment group and control group, with 34 cases in each group. Patients in the control group were given anticoagulant, antihypertensive and Insulin treatment, the treatment group patients in the control group plus enalapril and alprostadil treatment, after 4 weeks of treatment, the two groups of patients treated with good and renal function, and urinary protein levels before and after treatment changes. Results: The urinary protein measured 24 hours before treatment was no significant difference between two groups (P> 0.05), and the 24-hour urinary protein in the treatment group after treatment was (1.29 ± 0.13) g, The control group was (1.78 ± 0.32) g (P <0.05). The overall good rate of renal function in the treatment group was 91.18% higher than that in the control group (76.47%, P <0.05). Conclusion: Enalapril and alprostadil are effective in improving renal function and urinary protein levels in 24 h patients with diabetic nephropathy.