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为探讨血红素加氧酶／一氧化碳系统对动脉粥样硬化发病的影响，采用高胆固醇饮食建立了动脉粥样硬化家兔模型，并检测了血清总胆固醇、血浆氧化型低密度脂蛋白浓度及主动脉血红素加氧酶活性、一氧化碳生成量和主动脉内膜斑块面积。结果显示，高胆固醇饮食显著升高血清总胆固醇及血浆氧化型低密度脂蛋白浓度，血红素加氧酶活性及一氧化碳生成量分别较正常组降低４０％及３０％（Ｐ＜０．０１），主动脉斑块面积达４２．６％±９．２％；血红素Ｌ赖氨酸盐恢复了一氧化碳生成量（Ｐ＜０．０１），斑块面积减少至２８．４％±８．１％（Ｐ＜０．０５）。以上提示，动脉粥样硬化家兔主动脉血红素加氧酶／一氧化碳系统活性显著受损，血红素Ｌ赖氨酸盐通过恢复主动脉一氧化碳生成量而在一定程度上抑制动脉粥样硬化进展。
To investigate the effect of heme oxygenase / carbon monoxide system on the pathogenesis of atherosclerosis, a rabbit model of atherosclerosis was established by high cholesterol diet. The levels of serum total cholesterol, plasma oxidized low density lipoprotein Arterial heme oxygenase activity, carbon monoxide production and aortic intimal plaque area. The results showed that high cholesterol diet significantly increased serum total cholesterol and plasma oxidized low density lipoprotein concentrations, heme oxygenase activity and carbon monoxide production decreased by 40% and 30% (P <0.01), respectively, compared with the normal group, Aortic plaque area of 42.6% ± 9.2%; heme L-lysine salt to restore the amount of carbon monoxide (P <0.01), plaque area reduced to 28.4% ± 8. 1% (P <0.05). The above tips, atherosclerosis rabbit aortic heme oxygenase / carbon monoxide system activity significantly impaired, heme-L-lysine salt by restoring aortic carbon monoxide production and to some extent, inhibit atherosclerosis progress.