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目的探讨丙型肝炎病毒基因分型与感染方式、肝功能损伤程度的关系及干扰素疗效与基因型关系。方法采用５′－末端非编码区酶切基因分型技术检测血清ＨＣＶＲＮＡ基因型。结果有受血史患者以Ⅱ型ＨＣＶ感染为主，Ⅲ型多见于散发病例，Ｐ＜０．０５；Ⅱ型肝功能损伤重，Ｐ＜０．０５；Ⅲ型ＨＣＶＲＮＡ干扰素疗效好于Ⅱ型。结论肝功能损伤程度与基因分型有关，输血机会的增加使感染Ⅱ型ＨＣＶＲＮＡ机会增加，急性期干扰素抗病毒治疗有效
Objective To investigate the relationship between genotype and infection of hepatitis C virus, the degree of liver injury and the effect of interferon on genotypes. Methods Serum HCV RNA genotypes were detected by restriction endonuclease digestion with 5’-untranslated region. Results The patients with blood-stasis had type Ⅱ HCV infection, type Ⅲ was more common in sporadic cases, P <0.05; Type Ⅱ liver injury was severe, P <0.05; type Ⅲ HCVRNA interferon was better than type Ⅱ . Conclusions The degree of liver injury is related to genotyping. Increased blood transfusion opportunities increase the chance of infection with type ¢ ñ HCV RNA, and effective treatment with acute interferon antiviral therapy