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近年来,国内外对抗心律失常药物的研究发展很快,尤其是抗快速心律失常的新药使用较多。有些药物副作用较大,安全范围较窄。因此掌握各药的作用和药代动力学特点,特别是各药的不良反应,在临床上十分重要。本文重点介绍几种常用抗快速心律失常新药的各种不良反应。双异丙吡胺双异丙吡胺,又名达舒平(disopyramide)。国外在1954年合成,用于治疗室上性和室性快速型心律紊乱。对室上性、室性早搏,室上性和室性心动过速,心房纤维颤动后维持窦性心律,以及终止阵发性心房扑动、心房纤颤均有效。其电生理作用与奎尼丁相似,由于其降低心房、房室结和心室四位相的除极速率,减慢心肌传导速率和延长有效及功能性不应期而作为Ⅰ型抗心律失常药物。临床用法一般为
In recent years, the research on arrhythmic drugs at home and abroad has been developing rapidly, especially the new anti-tachyarrhythmia drugs. Side effects of some drugs larger, narrower range of safety. Therefore, to master the role of each drug and pharmacokinetic characteristics, especially the adverse reactions of various drugs, is clinically important. This article focuses on a variety of commonly used anti-tachyarrhythmia drugs of various adverse reactions. Disopyramide Diisopropylamine, also known as disopyramide. Abroad in 1954 synthesized for the treatment of supraventricular and ventricular tachyarrhythmia. Supraventricular, premature ventricular contractions, supraventricular and ventricular tachycardia, atrial fibrillation to maintain sinus rhythm, and the termination of paroxysmal atrial flutter, atrial fibrillation are effective. Its electrophysiological role is similar to that of quinidine because it decreases the rate of depolarization of the atria, atrioventricular and ventricular phases, slows the rate of myocardial conduction and prolongs the effective and functional refractory period as type I antiarrhythmic drugs. Clinical usage is generally