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目的 观察归芎消异方治疗中重度子宫内膜异位症的临床疗效及安全性.方法 将50例中重度子宫内膜异位症患者随机分为试验组和对照组,行保守性手术后分别予3个月的归芎消异方(试验组)或醋酸曲普瑞林(对照组)治疗,比较术前及术后12、24周血清癌抗原125 (CA125)、盆腔疼痛程度、复发率及不良反应发生率.结果 使用归芎消异方或醋酸曲普瑞林治疗后CA125水平和盆腔疼痛程度均较术前显著下降(P＜0.05);但试验组下降速度和幅度均较对照组弱(P＜0.05).试验组不良反应发生率低于对照组(13.64％ vs 39.13％,P＜0.01),而在盆腔疼痛缓解率和复发率方面2组间差异无统计学意义.结论 归芎消异方可有效缓解中重度子宫内膜异位症患者的盆腔疼痛症状,减缓复发,且相对安全、经济.“,”AIM To investigate the clinical effect and safety of Guixiong Xiaoyi Fang on moderate to severe endometriosis.METHODS Fifty patients of moderate to severe endometriosis were randomly divided into 2 groups,test group and control group,which were treated with Guixiong Xiaoyi Fang or triptorelin acetate for 3 months after a conservative operation.The changes were analyzed in serum carcinoma antigen 125 (CA125),degree of pelvic pain,recurrence rate and incidence of adverse drug reaction (ADR) after treatment.RESULTS There were significant decreases in CA125 and visual analogue pain score in both the 2 groups after treatment (P ＜0.05).Although the effects of triptorelin acetate were stronger (P ＜ 0.05),the incidence of ADR was also higher than Guixiong Xiaoyi Fang (39.13％ vs 13.64％,P ＜0.01).There was no statistical difference in pelvic pain relief and recurrence rate between 2 groups.CONCLUSION Guixiong Xiaoyi Fang is effective on treating chronic pelvic pain and slowing down the recurrence for patients with moderate to severe endometriosis.It is relatively safe and economic.