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目的评价血脂康对糖尿病患者颈动脉斑块的影响。方法入选302例合并颈动脉斑块而胆固醇在正常范围内的糖尿病患者,随机分为血脂康治疗组152例和常规治疗组150例,分别记录治疗前和治疗6、12个月血脂各项指标、超敏C反应蛋白(hs-CRP)及颈动脉斑块总面积,比较2组的血脂、hs-CRP及颈动脉斑块的变化。结果治疗6个月及12个月,血脂康治疗组总胆固醇、低密度脂蛋白胆固醇、三酰甘油均明显降低,hs-CRP也降低,颈动脉斑块总面积有所缩小,与治疗前相比,P<0.05;而常规治疗组治疗后血脂、hs-CRP及颈动脉斑块与治疗前比较差异均无统计学意义,但与血脂康治疗组同期相比,差异有统计学意义。结论血脂康对于合并颈动脉斑块的糖尿病患者不仅有很好的降脂疗效,而且有抑制炎症因子、缩小颈动脉斑块面积的作用。
Objective To evaluate the effect of Xuezhikang on carotid artery plaque in diabetic patients. Methods A total of 302 diabetic patients with carotid artery plaque and cholesterol in the normal range were randomly divided into Xuezhikang group (n = 152) and conventional treatment group (n = 150), and the indexes of blood lipids before and 6,12 months , Hs-CRP and carotid artery plaque area, and compared the changes of blood lipid, hs-CRP and carotid artery plaque in the two groups. Results After treatment for 6 months and 12 months, the total cholesterol, LDL-C and triglyceride in Xuezhikang treatment group were significantly decreased, the hs-CRP was also decreased, the total area of carotid artery plaque was reduced, P <0.05. However, there was no significant difference in the levels of serum lipids, hs-CRP and carotid artery plaque between the two groups after treatment, but there was a significant difference compared with that of the Xuezhikang treatment group at the same period. Conclusion Xuezhikang not only has good lipid-lowering curative effect on diabetic patients with carotid plaque, but also has the effect of inhibiting inflammatory factors and reducing carotid plaque area.