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目的 :观察承气方剂对MODS时肠道细菌移位的影响。 方法 :利用MODS动物模型 ,采用Dig probe大肠杆菌原位杂交的方法 ,观察MODS时肠道细菌移位及承气方剂和抗生素对其影响。 结果 :MODS时肠源性大肠杆菌可以移位到肠壁的粘膜下层甚至肌层 ,经淋巴系统和门静脉到达全身。与模型组比较 ,承气方剂治疗可以明显地抑制MODS大鼠肠道细菌移位 (P <0 .0 5 ) ;抗生素治疗不能抑制MODS大鼠肠道细菌移位。 结论 :承气方剂治疗MODS时通过对屏障功能的保护而在抑制肠道细菌移位发挥显著作用。抗生素治疗MODS时对肠道细菌移位无抑制作用。
Objective : To observe the effect of Chengqi Prescription on intestinal bacterial translocation during MODS. METHODS: Using MODS animal model, using Dig probe E. coli in situ hybridization method, observed the bacterial translocation of intestinal bacteria and effects of Chengqi formula and antibiotics on MODS. RESULTS: At the time of MODS, enterointestinal E.coli can be transposed into the submucosa and even the muscular layer of the intestinal wall and reach the whole body through the lymphatic system and the portal vein. Compared with the model group, Chengqi prescription treatment can significantly inhibit intestinal bacterial translocation in MODS rats (P < 0.05). Antibiotic treatment can not inhibit intestinal bacterial translocation in MODS rats. Conclusion : Chengqi Prescription can play a significant role in inhibiting bacterial translocation in the intestine by protecting the barrier function in the treatment of MODS. Antibiotic treatment of MODS had no inhibitory effect on intestinal bacterial translocation.