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目的:为验证“正虚挟瘀”是中医衰老的重要原因/机制的可靠性及合理性,我们观察了补肾健脾化瘀方对老年小鼠免疫功能、自由基代谢的影响。方法:老年小鼠连续四周灌服中药后,检测腹腔巨噬细胞产生的IL-1、脾淋巴细胞产生的IL-2、红细胞清除自由基酶(SOD、CAT、GSH-Px)的活性以及肝脑的LPO含量。结果:老年小鼠IL-1、IL-2的产生以及SOD、CAT、GSH-Px的酶活性均明显低于青年小鼠,而肝脑产生的过氧化脂质(LPO)明显增加。给药后,上述指标均可明显得到改善。结论:老年机体确为“虚”和“瘀”并存,进一步为我们的观点提供了实验依据;同时也说明IL-2的产生能力降低除与T细胞本身有关外,还与巨噬细胞、自由基代谢等因素有关。
OBJECTIVE: To verify the validity and rationality of “positive imaginary” as an important cause/mechanism of aging in traditional Chinese medicine, we observed the effect of Bushen Jianpi Huayu Recipe on immune function and free radical metabolism in old mice. METHODS: Old mice were treated with Chinese herbs for four weeks, and IL-1 produced by peritoneal macrophages, IL-2 produced by splenic lymphocytes, activity of red cell scavenging free radical enzymes (SOD, CAT, GSH-Px) and liver were detected. The LPO content of the brain. Results: The production of IL-1 and IL-2 in aged mice and the activity of SOD, CAT and GSH-Px were all significantly lower than that of young mice. The lipid peroxides (LPO) produced by liver and brain increased significantly. After administration, the above indicators can be significantly improved. Conclusion: The elderly body is indeed “virtual” and “convulsions” coexist, further providing experimental basis for our point of view; also shows that IL-2 production capacity is reduced in addition to the T cells themselves, but also with macrophages, free Base metabolism and other factors.