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应用光、电镜方法观察12只正常大鼠视网膜,12只实验性高血压大鼠视网膜,结果表明:高血压大鼠视网膜毛细血管基膜增厚,管腔狭窄致视网膜缺血缺氧引起节细胞和视细胞外节的病变.多数节细胞水肿、胞浆淡染、线粒体空泡化、滑面内质网扩张、部份粗面内质网扩张、脱粒;甚至有少数节细胞胞膜破裂与邻近节细胞胞浆相融合.而视细胞的改变主要在于外节中膜盘凌乱,排列不整齐,特别是外节基底部新生的膜盘病变为甚.视网膜中的?细胞对缺氧抗力较强,未见明显病变.
The retinas of 12 normal rats and 12 experimental hypertensive rats were observed by light and electron microscope. The results showed that retinal capillary basement membrane thickening and luminal stenosis caused retinal ischemia and hypoxia, And depending on the pathological changes of extracellular sections of most section of cell edema, pale stained cytoplasm, mitochondrial vacuoles, sliding endoplasmic reticulum expansion, part of the rough endoplasmic reticulum dilation, threshing; and even a few sections of the cell membrane rupture and Adjacent cells in the cytoplasm fusion, while the changes in the optic nerve mainly in the outer segment of the media disk messy, irregular arrangement, especially in the outer base of the new membrane disc disease is even more? Strong, no obvious lesions.