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金盏花属植物Calendula arvensis在意大利传统用作抗炎,抗癌及解热药。已从此植物的甲醇提取部分中分出四个三萜皂甙,从氯仿部分中分出一个epicubebol型倍半萜甙和四个alloaromadendro型倍半萜甙(化合物2～5)。本文报道了从氯仿部分中分出的两个新alloaromadendrol型倍半萜甙(化合物6, 7),并对所有倍半萜甙的体外抗病毒活性进行了研究。其分离过程如下: 植物地上部分在索氏提取器中依次以石油醚和氯仿提取。氯仿部分在硅胶柱上以氯仿-甲醇梯度洗脱。氯仿-甲醇(8:2)洗脱的第70至第83部分合并用硅胶薄层纯化,展
The calendula plant Calendula arvensis is traditionally used in Italy as an anti-inflammatory, anti-cancer and antipyretic agent. Four triterpene saponins have been isolated from the methanol fraction of this plant, and one epicupabery sesquiterpene and four alloaromadendro sesquiterpenes (compounds 2-5) have been separated from the chloroform fraction. Two new alloaromadendrol sesquiterpenoids (compounds 6, 7) isolated from the chloroform fraction were reported and the in vitro antiviral activity of all sesquiterpenes was studied. The isolation process is as follows: The aerial part of the plant is extracted with petroleum ether and chloroform sequentially in a Soxhlet extractor. The chloroform fraction was eluted on a silica gel column with a chloroform-methanol gradient. Fractions 70 to 83 eluted with chloroform-methanol (8:2) were purified using a thin layer of silica gel.