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目的研究Ｋｉ－６７蛋白表达与胃癌生物学特性的相关性。方法利用免疫组化方法对１２例Ｔ１期胃癌、２０例Ｔ２期胃癌组织的Ｋｉ－６７蛋白表达率进行测定，并分别在有淋巴结转移组和无淋巴结转移组之间进行对比研究。结果Ｋｉ－６７蛋白表达率与胃癌的淋巴结转移、浸润深度及生长方式明显相关。结论Ｋｉ－６７蛋白可作为判断胃癌淋巴结转移情况的分子生物学指标。
Objective To study the correlation between the expression of Ki-67 protein and the biological characteristics of gastric cancer. Methods The expression of Ki-67 protein in 12 cases of T1 gastric cancer and 20 cases of T2 gastric cancer was determined by immunohistochemistry. The results were compared between lymph node metastasis group and lymph node metastasis group. Results The expression rate of Ki-67 protein was significantly correlated with lymph node metastasis, depth of invasion, and growth pattern of gastric cancer. Conclusion Ki-67 protein can be used as a molecular biological marker to judge the lymph node metastasis of gastric cancer.