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自噬是真核细胞的Ⅱ型程序性细胞死亡过程，自噬失调会导致多种疾病的发生。该领域已经成为目前生物医学研究的热点，而通过调控自噬活性来防治疾病是重要的研发方向。研究表明，维生素D除具有维持机体钙磷代谢、介导免疫反应等功能外，还能介导自噬活性，参与多系统疾病的发生。深入了解维生素D的自噬调节功能及其与疾病的关系不仅有助于阐明疾病病理机制，还具有重要的实际应用意义。“,”Autophagy is typeⅡ programmed cell death process of all eukaryotic cells.Autophagy disor-ders can lead to a variety of diseases,and it has become a hot field of biomedical research.To prevent and treat diseases by regulating autophagy activity has become an important research direction .Studies have shown that vitamin D is not only involved in calcium and phosphorus metabolism ,immune response, but also capable of mediating autophagy activity,and related to multi-system diseases.Depth understanding of the autophagy function of vitamin D and its relationship with the diseases not only will help elucidate the patho-genesis of these diseases,but also have important practical significance.