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目的:探讨新疆地区冠心病与阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的关系。方法:连续入选疑似冠心病并伴夜间打鼾的住院患者146例,根据冠状动脉造影结果分为冠心病组和对照组,再行整夜睡眠监测,比较两组患者睡眠呼吸紊乱指数(AHI)、平均氧饱和度、最低氧饱和度和OSAHS发生情况。结果:冠心病组血糖水平、男性构成比均高于对照组(均P<0.05);冠心病组较对照组AHI[25.65(33.0)∶13.10(28.0),P=0.004]、清醒次数[(22.81±12.66)∶(17.48±9.51),P=0.013]、睡眠效率[(72.65±13.73)∶(66.97±16.25),P=0.032]、中重度OSAHS构成比(73.53%∶43.18%,P=0.001)均明显增加,而睡眠潜伏期明显少于对照组[19.50(41.0)∶31.50(76.0),P=0.011]。结论:新疆地区冠心病患者与中重度OSAHS相关,睡眠结构紊乱可能是导致冠心病的危险因素之一;男性、血糖水平增高亦与冠心病有关。
Objective: To investigate the relationship between coronary heart disease and obstructive sleep apnea-hypopnea syndrome (OSAHS) in Xinjiang. Methods: One hundred and sixty-six inpatients with suspected coronary heart disease and snoring at night were enrolled. According to coronary angiography results, they were divided into coronary heart disease group and control group. After overnight sleep monitoring, the sleep disturbance index (AHI) Average oxygen saturation, lowest oxygen saturation and OSAHS incidence. Results: Compared with the control group, the blood sugar level and male constitutional ratio in CHD group were significantly higher than those in control group (P <0.05). The AHI [25.65 (33.0 ):13.10 (28.0), P = 0.004] (P <0.05). The sleep efficiency was significantly higher in patients with severe OSAHS (22.81 ± 12.66, P = 0.013, P = 0.013) 0.001) were significantly increased, while sleep latency was significantly less than the control group [19.50 (41.0): 31.50 (76.0), P = 0.011]. Conclusion: The patients with coronary heart disease in Xinjiang are associated with moderate-severe OSAHS. The disturbance of sleep structure may be one of the risk factors leading to coronary heart disease. In men, the elevated blood glucose level is also associated with coronary heart disease.