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本文主要针对直接作用于肿瘤细胞的高效抗肿瘤药物,也对肿瘤研究中其它更微妙的领域加以综述。有关细胞分化的生物化学基础及其用于化疗的潜在可能性已有所综述。作为抗细胞增殖剂和分化诱导剂的维生素A酯类及六次甲基双乙酰胺的早期临床经验也已综述。正在阐明转移侵害的生化理论,当该方法确立时,就会发展抗转移的药物。已分离和鉴定了两个直接参与癌变过程的蛋白质。血管素从人体腺癌HT-29细胞株中分离而得。它含123个氨基酸,在10~(-12)～10~(-5)克分子浓度时引起血管增生,其氨基
This article focuses on highly effective antitumor drugs that act directly on tumor cells, as well as other more subtle fields in cancer research. The biochemical basis for cell differentiation and its potential for chemotherapy have been reviewed. Early clinical experience with vitamin A esters and hexamethyldiethanolamine as anti-cell proliferative and differentiation inducing agents has also been reviewed. Biochemical theories of metastasis violations are being elucidated, and when the method is established, anti-metastatic agents are developed. Two proteins that are directly involved in the carcinogenesis have been isolated and identified. Angiogenin is isolated from the human adenocarcinoma HT-29 cell line. It contains 123 amino acids and causes hyperplasia at 10 ~ (-12) ~ 10 ~ (-5)