论文部分内容阅读
本文采用放射免疫测定法、原子吸收光谱分析法和生化酶分析法,测定了大鼠在经受束缚加浸水急性应激四小时内,胃组织cAMP Ca~(2+)及在ATP、ADP、AMP和能量代谢的短期动态变化,同时观察了胃粘膜的损害程度。结果发现胃粘膜损害面积密度随着应激时间延长而逐渐增加;胃组织cAMP和Ca~(2+)则进行性降低;两者呈密切负相关;胃组织能量代谢却略有增强。若预先给以CaCl_2,再予应激,则有减轻应激性胃粘膜损害的作用。
In this paper, radioimmunoassay, atomic absorption spectrometry and biochemical enzyme assay were used to determine the rat cAMP Ca~(2+) and ATP, ADP, AMP in gastric tissue within four hours of acute stress under binding and infusion. And the short-term dynamic changes in energy metabolism, while observing the degree of gastric mucosal damage. The results showed that the area density of gastric mucosal lesions gradually increased with prolonged stress; cAMP and Ca 2+ were progressively decreased in gastric tissue; there was a close negative correlation between the two, and the energy metabolism in gastric tissue was slightly enhanced. If CaCl 2 is given in advance and re-stressed, the effect of reducing stress-induced gastric mucosal damage can be mitigated.