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目的:观察N末端脑钠肽前体检测在不完全川崎病早期诊断中的作用。方法:本次选取我院2013年3月16日~2017年3月17日住院部收治的不完全川崎病患者40例——观察组,并同时选择50例健康儿童——对照组,对两组患者的N末端脑钠肽前体水平进行检测。结果:观察组患者的急性期N末端脑钠肽前体水平(0.88±0.23ug/L)高于恢复期水平(P<0.05),而对照组患者的N末端脑钠肽前体(0.09±0.03ug/L)低于观察组患者的急性期、恢复期(P<0.05);观察组合并冠脉病变的N末端脑钠肽前体水平为(0.85±0.13ug/L)、无冠脉病变组为(0.85±0.12ug/L),两组患者对比的数据无差异(P>0.05)。结论:不完全川崎病患者的血浆N末端脑钠肽前体水平高于正常儿童,其指标参与不完全川崎病的过程,根据N末端脑钠肽前体值进行诊断,有助于医生对患者病情的评估和治疗。
Objective: To observe the role of N-terminal pro brain natriuretic peptide in the early diagnosis of incomplete Kawasaki disease. Methods: Forty patients with incomplete Kawasaki disease treated in our hospital from March 16, 2013 to March 17, 2017 were selected as the observation group and 50 healthy children - control group Group of patients with N-terminal pro-brain natriuretic peptide levels were detected. Results: The level of N-terminal pro-brain natriuretic peptide (0.88 ± 0.23ug / L) in the observation group was higher than that in the recovery stage (P <0.05), while the N-terminal pro brain natriuretic peptide (0.09 ± 0.03ug / L) were lower than those in the observation group (P <0.05). The level of N-terminal pro-brain natriuretic peptide in the coronary artery disease group was (0.85 ± 0.13ug / L) The lesion group was (0.85 ± 0.12ug / L), there was no difference between the two groups (P> 0.05). CONCLUSIONS: Plasma N-terminal pro-brain natriuretic peptide levels in patients with incomplete Kawasaki disease are higher than those in normal children and their parameters are involved in the process of incomplete Kawasaki disease. Diagnosis based on N-terminal pro brain natriuretic peptide is helpful to doctors in treating patients Disease evaluation and treatment.